Cell：感染“训练”宿主，“升级”菌群对病原体的抵抗力 | 热心肠日报
[IF:38.637]
Infection trains the host for microbiota-enhanced resistance to pathogens
感染训练宿主增强菌群对病原体的抵抗力
10.1016/j.cell.2020.12.011
01-15, Article
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The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process remains largely unknown. Here, we show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to the expansion of taxa that utilize the sulfonic acid taurine. Notably, supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Mechanistically, taurine potentiates the microbiota’s production of sulfide, an inhibitor of cellular respiration, which is key to host invasion by numerous pathogens. As such, pharmaceutical sequestration of sulfide perturbs the microbiota’s composition and promotes pathogen invasion. Together, this work reveals a process by which the host, triggered by infection, can deploy taurine as a nutrient to nourish and train the microbiota, promoting its resistance to subsequent infection.
First Authors:
Apollo Stacy
Correspondence Authors:
Apollo Stacy,Yasmine Belkaid
All Authors:
Apollo Stacy,Vinicius Andrade-Oliveira,John A McCulloch,Benedikt Hild,Ji Hoon Oh,P Juliana Perez-Chaparro,Choon K Sim,Ai Ing Lim,Verena M Link,Michel Enamorado,Giorgio Trinchieri,Julia A Segre,Barbara Rehermann,Yasmine Belkaid