每天一个人名反应--Combes喹啉合成反应
苯胺和β-二酮在酸催化下组合成喹啉。参见Conrad-Limpach反应。
反应机理
一个电环化机理也是可能的
反应实例
参考文献
1. Combes, A. Bull. Soc. Chim. Fr. 1888, 49,89.
2. Roberts, E. and Turner, E. J.Chem Soc. 1927, 1832-1857. (Review).
3. Elderfield, R. C. In HeterocyclicCompounds, Elderfield, R. C., ed.; Wiley: New York, 1952, vol. 4, 36–38. (Review).
4. Popp, F. D. and McEwen, W.E. Chem. Rev. 1958, 58, 321–401. (Review).
5. Jones, G. In Chemistry ofHeterocyclic Compounds, Jones, G., ed.; Wiley & Sons, New York, 1977,QuinolinesVol. 32, pp 119–125. (Review).
6. Alunni-Bistocchi, G.;Orvietani, P., Bittoun, P., Ricci, A.; Lescot, E. Pharmazie 1993, 48, 817-820.
7. El Ouar, M.; Knouzi, N.;Hamelin, J. J. Chem. Res. (S) 1998, 92-93.
8. Curran, T. T. CombesQuinoline Synthesis. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp 390-397.(Review).
摘自:有机人名反应——机理及应用 第四版