Dr. Xu Yanjun, may be the first person to propose the idea of nasal immunity for the new crown pneumonia virus COVID-19 (the information is used for discussion only with medical professionals)
Dr. Xu Yanjun, may be the first person to propose the idea of nasal immunity for the new crown pneumonia virus COVID-19 (the information is used for discussion only with medical professionals)
-Qi Que
The nasal immunization method of the new crown pneumonia virus has achieved good results in animal experiments in several countries. The United Kingdom may plan to carry out human nasal immunization experiments. Who is the earliest, public, and well-documented person who proposed this experiment? On April 7th and 14th, 2020, Yanjun Xu, a PhD in pharmacology, published two ideas for nasal cavity experiments on the WeChat public account of "Overseas Travellers Micro Life". And in English, these two ideas were sent to WHO, NIH, Health Canada, and .... The original text is as follows:
Dr. Xu Yanjun's views on the new crown pneumonia virus
Xu Yanjun Micro Life of Overseas Travellers 2020-04-07
I. Discussion on simple immunization methods for new coronary pneumonia virus or other unknown respiratory viruses-This article is only for communication and discussion among scientific researchers, and it is prohibited to try.
Dr. Xu Yanjun
At present, there is no specific drug treatment and vaccine prevention for the new crown pneumonia virus. It takes at least 6 months for the vaccine to be used clinically. To this end, referring to the ancient Chinese method of immunity to smallpox, a simple and practical method is designed for prevention and immunity.
...
Detect the content of inactivated virus in the liquid, put a few drops of liquid into the nasal cavity of normal people, and then test the human antibody after three consecutive days of nasal drip. If there are antibodies, the immunization will be successful.
If the virus is inactivated, it cannot produce immunity. Consider using attenuated (reduced to the pathogenicity of the virus) virus. There are many ways to deactivate, such as controlling the temperature and time of disinfection or chemical treatment. All these require scientific experiments to find a simple and reliable method.
However, the effects and side effects of this method are still unknown, so don't try it yourself.
COVID19 Respiratory Virus Immunization Cabin Design
Xu Yanjun Micro Life of Overseas Travellers 2020-04-14
Immunization cabin: Exploration of immunization methods against the new crown pneumonia virus (COVID-19) or other unknown respiratory viruses-this article is only used for exchanges and discussions between scientific researchers, and trials are prohibited.
Dr Xu Yanjun
If we can draw a curve of the relationship between the number of viruses in the air and the pathogenicity, and find out how many viruses are infected that will not cause disease, but have developed immunity, we can control the number of viruses in the air to achieve immunity. The purpose of this is to reduce the risk of disease and outbreak. For example, through scientific experiments, it is concluded that inhaling 10 viruses is a safe dose, and a specific device is used to control the viruses in the air within this range, so that people can be infected with less than 10 viruses. Neither disease, but also immunity. Or use inhaled attenuated viruses that are not enough to cause disease.
The author assumes no responsibility for whether the contents in the articles are correct, whether the methods are harmful, or for other possibilities. The content in this article is only for discussion with medical researchers. Do not try to avoid danger.
(Translate by Google)
徐彦君博士，可能是地球上最早提出新冠肺炎病毒COVID-19 鼻腔免疫设想的人
- 岐鹊
新冠肺炎病毒的鼻腔免疫方法在几个国家的动物实验上取得了良好的效果，英国计划开展人体的鼻腔免疫实验。谁是最早的、公开的、有据可查的、提出这个实验设想的人呢？药理学博士徐彦君在2020年4月7号和14号份在《海外游子微生活》的微信公众号上发布了鼻腔实验的两个设想。并用英语把这两个设想发给了 WHO, NIH, Health Canada ... 和国内的有关部门。原文如下：
徐彦君博士对新冠肺炎病毒的看法
徐彦君 海外游子微生活 2020-04-07
I.对新冠肺炎病毒或其它未知的呼吸道病毒的简单免疫方法的探讨-本文仅用于科研人员的交流和讨论，禁止试用。
徐彦君博士
目前对新冠肺炎病毒还没有特效药物治疗和疫苗防疫。疫苗至少需要6个月才有可能用于临床。为此，参考中国古代对天花的免疫方法，设计一个简单实用的方法用于预防和免疫。
我有一个初步的想法，给病人发放75%的医用酒精湿纱布，病人打喷嚏或咳嗽的时候对着这样的纱布，使病毒吸附在纱布上。收集这些纱布，将纱布浸泡在生理盐水里，搅拌10分钟，使病毒脱落于液体中，高温加热 （100摄氏度，30分钟），使病毒彻底的灭活。
检测液体中灭活病毒含量，给正常人的鼻腔滴入几滴液体，连续滴鼻三天后，检测人体的抗体。如果有了抗体，免疫就成功了。如果灭活的病毒不能通过鼻黏膜进入血液，可考虑先给动物微量注射，检查其效果和安全性。
如果灭活的病毒，不能产生免疫力。可考虑用减活（降到病毒的致病力）的病毒。减活的方法有很多，如控制消毒的温度和时间或化学处理。这些都需要经过科学实验后，才能找到一个简单易行而且可靠的方法。
这个方法简单实用，可用于任何新的呼吸道病毒的早期免疫（即在标准的疫苗用于临床之前）。但这个方法的效果和副作用如何，尚不得而知，因此不要自己试用。
作者对文中内容是否正确，是否有害及对其它的可能性均不承担任何责任。文中内容仅用于和医学研究人员讨论。万勿试用，以免造成危险。
II. 对新冠肺炎病毒或其它未知的呼吸道病毒的简单免疫方法的探讨-本文仅用于科研人员的交流和讨论，禁止试用。 徐彦君博士 现在有的地区实行全民免疫，也就是被动免疫，这个方法有疫情扩散的风险。如果我们能画出一个空气中病毒的数量和致病性的关系曲线，找出感染了多少个病毒不会致病，但产生了免疫力，就可以通过控制吸入空气中病毒了数量，达到免疫的目的，也减少了致病和爆发的风险。例如，通过科学实验得出结论：吸入10个病毒是安全的剂量，就用一个特定的装置就把空气中的病毒控制在这个范围内，使人感染在10个病毒以内。既不发病，还能产生免疫力。或采用吸入不够致病数量的减活的病毒。 诚然，这个参考古代的免疫方法，有许多的疑问，效果也肯定不如现代科技手段生产的疫苗，但是否可以作为应急呢？希望本文能起到开发思路，集思广益和抛砖引玉的作用。 作者对文中内容是否正确，是否有害及对其它的可能性均不承担任何责任。文中内容仅用于和医学研究人员讨论。万勿试用，以免造成危险。
COVID19 呼吸道病毒免疫方舱的设计
徐彦君 海外游子微生活 2020-04-14
免疫方舱：对新冠肺炎病毒（COVID-19)或其它未知的呼吸道病毒的免疫方法的探索-本文仅用于科研人员的交流和讨论，禁止试用。
徐彦君博士
现在有的地区实行全民免疫，也就是被动免疫，这个方法有疫情扩散的风险。如果我们能画出一个空气中病毒的数量和致病性的关系曲线，找出感染了多少个病毒不会致病，但产生了免疫力，就可以通过控制吸入空气中病毒了数量，达到免疫的目的，也减少了致病和爆发的风险。例如，通过科学实验得出结论：吸入10个病毒是安全的剂量，就用一个特定的装置就把空气中的病毒控制在这个范围内，使人感染在10个病毒以内。既不发病，还能产生免疫力。或采用吸入不够致病数量的减活的病毒。
这个免疫方舱要绝对密不透气的，温度可控的。通过控制温度的变化，使病毒减活。
这个免疫方舱的方法，有许多的不足之处。效果也肯定不如现代科技手段生产的疫苗，但是否可以作为应急呢？希望本文能起到开发思路，集思广益和抛砖引玉的作用。
作者对文中内容是否正确，是否有害及对其它的可能性均不承担任何责任。文中内容仅用于和医学研究人员讨论。万勿试用，以免造成危险。